A major barrier to converting cancer therapies into cures is drug resistance. Cancer cells often develop resistance to even the most effective therapies. For instance, anti-VEGF therapies dramatically reduce tumor size initially, but some studies find that this response is only transient and tumors resume growth and progression after long-term treatment. Basic cell biology is critically needed to characterize these resistance pathways and uncover tools for monitoring the emergence of resistance pathways.
Image: A freeze-fracture SEM of a blood vessel that has grown into a melanoma and is providing nourishment to it. Numerous red blood cells can be seen within the blood vessel.
Detail from the Etruscan Larthia Seianti sarcophagus, About 175-150 AD, From Chiusi, Siena.
Photo taken by Egisto Sani:
The cover of this terracotta sarcophagus depicts Larthia Seianti, a rich lady lived in the South Tuscany near Chiusi. The woman is portrayed lying-down on a kline. She is wearing a sumptuous and colorful clothing, and her figure is adorned by rich jewelry. The left arm is leaning against two colored cushions; her left hand, with the fingers richly decorated by rings, holds a round mirror. Her right hand puts away from the face the cloak covering her head.
A diadem made by flowers, presumably a wreath, embellishes her hair. A necklace decorated with a medallion representing Medusa’s head, is hanging around her neck. Two gold coronation bracelets, armillas, and red earrings in the shape of acorns complete the ornament of Larthia Seianti. (x)
Courtesy & currently located at the Museo Archeologico Etrusco, Florence.
The human brain in cross section