A major barrier to converting cancer therapies into cures is drug resistance. Cancer cells often develop resistance to even the most effective therapies. For instance, anti-VEGF therapies dramatically reduce tumor size initially, but some studies find that this response is only transient and tumors resume growth and progression after long-term treatment. Basic cell biology is critically needed to characterize these resistance pathways and uncover tools for monitoring the emergence of resistance pathways.
Image: A freeze-fracture SEM of a blood vessel that has grown into a melanoma and is providing nourishment to it. Numerous red blood cells can be seen within the blood vessel.








